Article
The changes in mycolic acid structures caused by hadC mutation have a dramatic effect on the virulence of Mycobacterium tuberculosis.
Molecular microbiology - 1 Feb 2016
Slama Nawel, Jamet Stevie, Frigui Wafa, Pawlik Alexandre, Bottai Daria, Laval Françoise, Constant Patricia, Lemassu Anne, Cam Kaymeuang, Daffé Mamadou, Brosch Roland, Eynard Nathalie, Quémard Annaïk
Abstract excerpt
Understanding the molecular strategies used by Mycobacterium tuberculosis to invade and persist within the host is of paramount importance to tackle the tuberculosis pandemic. Comparative genomic surveys have revealed that hadC, encoding a subunit of the HadBC dehydratase, is mutated in the avirulent M. tuberculosis H37Ra strain. We show here that mutation or deletion of hadC affects the biosynthesis of...
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