A common mechanism of inhibition of the Mycobacterium tuberculosis mycolic acid biosynthetic pathway by isoxyl and thiacetazone.

doi:10.1074/jbc.M112.400994

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Article

A common mechanism of inhibition of the Mycobacterium tuberculosis mycolic acid biosynthetic pathway by isoxyl and thiacetazone.

The Journal of biological chemistry - 9 Nov 2012

Grzegorzewicz Anna E, Korduláková Jana, Jones Victoria, Born Sarah E M, Belardinelli Juan M, Vaquié Adrien, Gundi Vijay A K B, Madacki Jan, Slama Nawel, Laval Françoise, Vaubourgeix Julien, Crew Rebecca M, Gicquel Brigitte, Daffé Mamadou, Morbidoni Hector R, Brennan Patrick J, Quémard Annaik, McNeil Michael R, Jackson Mary

Abstract excerpt

Isoxyl (ISO) and thiacetazone (TAC), two prodrugs once used in the clinical treatment of tuberculosis, have long been thought to abolish Mycobacterium tuberculosis (M. tuberculosis) growth through the inhibition of mycolic acid biosynthesis, but their respective targets in this pathway have remained elusive. Here we show that treating M. tuberculosis with ISO or TAC results in both cases in the accumulation of...

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PMID: 23002234
DOI: 10.1074/jbc.M112.400994
PMCID: PMC3493888

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