Article
Genomic convergence in hibernating mammals elucidates the genetics of metabolic regulation in the hypothalamus
31 Jul 2025
Abstract excerpt
Extreme metabolic adaptations can elucidate genetic programs that govern mammalian metabolism. Here, we used convergent evolutionary changes in hibernating lineages to define conserved cis-regulatory elements (CREs) and metabolic programs. We characterized mouse hypothalamus gene expression and chromatin dynamics across fed, fasted, and refed states and then used comparative genomics of hibernating versus...
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