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Identification of cancer sex-disparity in the functional integrity of p53 and its X chromosome network

26 Nov 2019

Abstract excerpt

The disproportionately high prevalence of male cancer is poorly understood. We tested for sex-disparity in the functional integrity of the major tumor suppressor p53 in sporadic cancers. Our bioinformatics analyses expose three novel levels of p53 impact on sex-disparity in 12 non-reproductive cancer types. First, TP53 mutation is more frequent in these cancers among US males than females, with poorest survival...

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Share to Cancer-related Molecular Pathways
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PMID: 31772231
DOI: 10.1038/s41467-019-13266-3

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