Article
Sex-based molecular and prognostic disparities in pan-cancer: an analysis across the global cohorts.
Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico - 1 May 2026
Sivakumar Guruguhan, Patra Tapas, Veeraiyan Durgadevi, Namani Akhileshwar
Abstract excerpt
BACKGROUND: Biological sex influences cancer risk, molecular profiles, and clinical outcomes, yet its role in non-reproductive cancers remains underexplored. METHODS: This study investigated sex-based differences in somatic mutations, copy number alterations (CNAs), and overall survival (OS) across 34,782 patients from three global pan-cancer cohorts (TCGA, MSK MetTropism, and China OrigiMed), excluding...
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