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Article

Loss of fragile X mental retardation protein precedes Lewy pathology in Parkinson's disease.

Acta neuropathologica - 1 Feb 2020

Tan Yi, Sgobio Carmelo, Arzberger Thomas, Machleid Felix, Tang Qilin, Findeis Elisabeth, Tost Jorg, Chakroun Tasnim, Gao Pan, Höllerhage Mathias, Bötzel Kai, Herms Jochen, Höglinger Günter, Koeglsperger Thomas

Abstract excerpt

Parkinson's disease (PD) is the most common neurodegenerative movement disorder and is characterized by the progressive loss of dopaminergic (DA) neurons in the substantia nigra pars compacta (SNc) and the gradual appearance of α-synuclein (α-syn)-containing neuronal protein aggregates. Although the exact mechanism of α-syn-mediated cell death remains elusive, recent research suggests that α-syn-induced...

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PMID: 31768670
DOI: 10.1007/s00401-019-02099-5

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