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Article

Alpha-synuclein enhances dopamine D2 receptor signaling.

Brain research - 8 Dec 2006

Kim Sung Jae, Kim Sung Yul, Na Young-Soon, Lee Hyun Jung, Chung Kwang Chul, Baik Ja-Hyun

Abstract excerpt

Parkinson's disease (PD) is characterized by a selective loss of dopamine-producing neurons in the substantia nigra (SN), which in turn results in dopamine depletion in the striatum, and the presence of neuronal cytoplasmic inclusions known as Lewy bodies (LBs). Alpha-synuclein is a presynaptic protein that accumulates abnormally in LBs and is seen predominantly in cases of dementia with LBs. Although the central...

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Identifiers

PMID: 17087919
DOI: 10.1016/j.brainres.2006.09.079

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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