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Article

Roles for α-Synuclein in Gene Expression

29 Jul 2021

Abstract excerpt

α-Synuclein (α-Syn) is a small cytosolic protein associated with a range of cellular compartments, including synaptic vesicles, the nucleus, mitochondria, endoplasmic reticulum, Golgi apparatus, and lysosomes. In addition to its physiological role in regulating presynaptic function, the protein plays a central role in both sporadic and familial Parkinson's disease (PD) via a gain-of-function mechanism. Because of...

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PMID: 34440340
DOI: 10.3390/genes12081166

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