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Article

α-synuclein promotes neuroprotection through NF-κB-mediated transcriptional regulation of protein kinase Cδ.

Science signaling - 18 Oct 2011

Aoki Reina, Li Yun Rose

Abstract excerpt

Parkinson's disease (PD) is a neurodegenerative disorder that results in a progressively debilitating loss of motor function and hypokinesia and is characterized by the selective loss of dopaminergic neurons in the substantia nigra pars compacta. Recent evidence suggests that caspase-3-dependent proteolytic cleavage and nuclear translocation of the δ isoform of protein kinase C (PKCδ) may be required for...

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PMID: 22009151
DOI: 10.1126/scisignal.2002425

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