Article

PrP <sup>C</sup> -induced signaling in human neurons activates phospholipase Cɣ1 and an Arc/Arg3.1 response

2025-04-05

Abstract excerpt

Synaptic dysfunction and loss correlate with cognitive decline in neurodegenerative diseases, including Alzheimer’s disease (AD) and prion disease. Neuronal hyperexcitability occurs in the early stages of AD and experimental prion disease, prior to the onset of dementia, yet the underlying drivers are unclear. Here we identify an increase in the immediate early gene, Arc/Arg3.1, in the human prion disease-affected...

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Literature Corpus work: a8007a85-429c-52de-af66-e5b8d697118d
DOI: 10.1101/2025.04.01.645054

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PrP <sup>C</sup> -induced signaling in human neurons activates phospholipase Cɣ1 and an Arc/Arg3.1 responseDOI 10.1101/2025.04.01.645054Read

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