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Article

Inhibition of FK506 binding proteins reduces alpha-synuclein aggregation and Parkinson's disease-like pathology.

The Journal of neuroscience : the official journal of the Society for Neuroscience - 17 Feb 2010

Gerard Melanie, Deleersnijder Angélique, Daniëls Veronique, Schreurs Sarah, Munck Sebastian, Reumers Veerle, Pottel Hans, Engelborghs Yves, Van den Haute Chris, Taymans Jean-Marc, Debyser Zeger, Baekelandt Veerle

Abstract excerpt

alpha-Synuclein (alpha-SYN) is a key player in the pathogenesis of Parkinson's disease (PD). In pathological conditions, the protein is present in a fibrillar, aggregated form inside cytoplasmic inclusions called Lewy bodies. Members of the FK506 binding protein (FKBP) family are peptidyl-prolyl...

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Identifiers

PMID: 20164329
DOI: 10.1523/JNEUROSCI.5983-09.2010
PMCID: PMC6634531

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-20164329-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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