The long non-coding RNA HOXB-AS3 regulates ribosomal RNA transcription in NPM1-mutated acute myeloid leukemia.

doi:10.1038/s41467-019-13259-2

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Community

Back to search

Article

The long non-coding RNA HOXB-AS3 regulates ribosomal RNA transcription in NPM1-mutated acute myeloid leukemia.

Nature communications - 25 Nov 2019

Papaioannou Dimitrios, Petri Andreas, Dovey Oliver M, Terreri Sara, Wang Eric, Collins Frances A, Woodward Lauren A, Walker Allison E, Nicolet Deedra, Pepe Felice, Kumchala Prasanthi, Bill Marius, Walker Christopher J, Karunasiri Malith, Mrózek Krzysztof, Gardner Miranda L, Camilotto Virginia, Zitzer Nina, Cooper Jonathan L, Cai Xiongwei, Rong-Mullins Xiaoqing, Kohlschmidt Jessica, Archer Kellie J, Freitas Michael A, Zheng Yi, Lee Robert J, Aifantis Iannis, Vassiliou George, Singh Guramrit, Kauppinen Sakari, Bloomfield Clara D, Dorrance Adrienne M, Garzon Ramiro

Abstract excerpt

Long non-coding RNAs (lncRNAs) are important regulatory molecules that are implicated in cellular physiology and pathology. In this work, we dissect the functional role of the HOXB-AS3 lncRNA in patients with NPM1-mutated (NPM1mut) acute myeloid leukemia (AML). We show that HOXB-AS3 regulates the proliferative capacity of NPM1mut AML blasts in vitro and in vivo. HOXB-AS3 is shown to interact with the...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to K562 Cells

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Leukemia, Myeloid

Share to Mice, Inbred NOD

Share to Mice, SCID

Share to Nucleophosmin

Share to RNA, Ribosomal

Share to THP-1 Cells

Share to Transplantation, Heterologous

Source

Open in PubMed Open full text

Identifiers

PMID: 31767858
DOI: 10.1038/s41467-019-13259-2
PMCID: PMC6877618

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The long non-coding RNA HOXB-AS3 regulates ribosomal RNA transcription in NPM1-mutated acute myeloid leukemia.PMID 31767858Read ↗

The RNA-binding protein IGF2BP3 is critical for MLL-AF4-mediated leukemogenesisSemantic proximity Read ↗

HOXBLINC long non-coding RNA activation promotes leukemogenesis in NPM1-mutant acute myeloid leukemia.Semantic proximity Read ↗

The Role of Hox Proteins in Leukemogenesis: Insights Into Key Regulatory Events in HematopoiesisSemantic proximity Read ↗

Post-transcriptional gene regulation by the RNA binding protein IGF2BP3 is critical for MLL-AF4 mediated leukemogenesisSemantic proximity Read ↗

From mRNA Metabolism to Cancer Therapy: Chronic Myelogenous Leukemia Shows the WaySemantic proximity Read ↗

HOXD-AS1 is a novel lncRNA encoded in HOXD cluster and a marker of neuroblastoma progression revealed via integrative analysis of noncoding transcriptomeSemantic proximity Read ↗

NPM1 mutation mediated HOXBLINC lncRNA activation promotes AML leukemogenesisSemantic proximity Read ↗

Focused CRISPR-Cas9 genetic screening reveals USO1 as a vulnerability in B-cell acute lymphoblastic leukemia.Semantic proximity Read ↗

hnRNP A1 nucleocytoplasmic shuttling activity is required for normal myelopoiesis and BCR/ABL leukemogenesis.Semantic proximity Read ↗

The stem cell–specific long noncoding RNA HOXA10-AS in the pathogenesis of KMT2A-rearranged leukemiaSemantic proximity Read ↗

RNA-binding protein IGF2BP3 targeting of oncogenic transcripts promotes hematopoietic progenitor proliferationSemantic proximity Read ↗

LncRNA-mediated organization of oncogenic chromatin state is a targetable vulnerability in leukemiaSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.