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PBX3 is an important cofactor of HOXA9 in leukemogenesis

22 Dec 2012

Abstract excerpt

Although PBX proteins are known to increase DNA-binding/transcriptional activity of HOX proteins through their direct binding, the functional importance of their interaction in leukemogenesis is unclear.We recently reported that overexpression of a 4-homeobox-gene signature (ie, PBX3/HOXA7/HOXA9/HOXA11) is an independent predictor of poor survival in patients with cytogenetically abnormal acute myeloid leukemia...

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PMID: 23264595
DOI: 10.1182/blood-2012-07-442004

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