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Article

From mRNA Metabolism to Cancer Therapy: Chronic Myelogenous Leukemia Shows the Way

15 Mar 2007

Abstract excerpt

Altered mRNA metabolism is a feature of many cancers including blast crisis chronic myelogenous leukemia. Indeed, loss of function of many tumor suppressors regulating cell proliferation, survival, and differentiation results from aberrant mRNA processing, nuclear export, and/or translation. Here, we summarize the effects of increased BCR/ABL oncogenic activity on the expression and function of RNA binding...

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PMID: 17363515
DOI: 10.1158/1078-0432.ccr-06-2320

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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