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The Role of Hox Proteins in Leukemogenesis: Insights Into Key Regulatory Events in Hematopoiesis

1 Jan 2011

Abstract excerpt

Acute myeloid leukemia (AML) is a heterogeneous disease with highly variable prognoses. Identification of recurring chromosomal translocations provides some prognostic information for individual AML subjects. Population based gene-expression profiling studies also identified abnormalities relevant to prognosis. Such studies associate increased expression of a set of homeodomain transcription factors with poor...

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PMID: 22150308
DOI: 10.1615/critrevoncog.v16.i1-2.70

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