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Article

Targeting specificity of APOBEC-based cytosine base editor in human iPSCs determined by whole genome sequencing.

Nature communications - 25 Nov 2019

McGrath Erica, Shin Hyunsu, Zhang Linyi, Phue Je-Nie, Wu Wells W, Shen Rong-Fong, Jang Yoon-Young, Revollo Javier, Ye Zhaohui

Abstract excerpt

DNA base editors have enabled genome editing without generating DNA double strand breaks. The applications of this technology have been reported in a variety of animal and plant systems, however, their editing specificity in human stem cells has not been studied by unbiased genome-wide analysis. Here we investigate the fidelity of cytidine deaminase-mediated base editing in human induced pluripotent stem cells...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 31767844
DOI: 10.1038/s41467-019-13342-8
PMCID: PMC6877639

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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