Article
Chromatin structure-based prediction of recurrent noncoding mutations in cancer.
Nature genetics - 1 Nov 2016
Kim Kwoneel, Jang Kiwon, Yang Woojin, Choi Eun-Young, Park Seong-Min, Bae Mingyun, Kim Youn-Jae, Choi Jung Kyoon
Abstract excerpt
Recurrence is a hallmark of cancer-driving mutations. Recurrent mutations can arise at the same site or affect the same gene at different sites. Here we identified a set of mutations arising in individual samples and altering different cis-regulatory elements that converge on a common gene via chromatin interactions. The mutations and genes identified in this fashion showed strong relevance to cancer, in contrast...
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