Article
NRASQ61K mutated diffuse leptomeningeal melanomatosis in an adult patient with a brief review of the so-called "forme fruste" of neurocutaneous melanosis.
Brain tumor pathology - 1 Oct 2018
Girolami Ilaria, Cima Luca, Ghimenton Claudio, Zannoni Marina, Mombello Aldo, Riva Giulio, Cirielli Vito, Corradi Gabriele, Vogrig Alberto, Di Stefano Gioia, Novelli Luca, Gessi Marco, Eccher Albino
Abstract excerpt
Primary melanocytic tumors of central nervous system represent rare tumors arising from melanocytes of the leptomeninges. These neoplasms include focal forms like melanocytoma and primary malignant melanoma and diffuse forms like leptomeningeal melanocytosis and primary leptomeningeal melanomatosis. The clinical diagnosis remains challenging, with clinical and radiologic features overlapping with other more...
Topics
- Adult
- Autopsy
- Brain
- Fatal Outcome
- GTP Phosphohydrolases
- Humans
- Magnetic Resonance Imaging
- Male
- Melanoma
- Melanosis