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Article

TMC1 and TMC2 Proteins Are Pore-Forming Subunits of Mechanosensitive Ion Channels.

Neuron - 22 Jan 2020

Jia Yanyan, Zhao Yimeng, Kusakizako Tsukasa, Wang Yao, Pan Chengfang, Zhang Yuwei, Nureki Osamu, Hattori Motoyuki, Yan Zhiqiang

Abstract excerpt

Transmembrane channel-like (TMC) 1 and 2 are required for the mechanotransduction of mouse inner ear hair cells and localize to the site of mechanotransduction in mouse hair cell stereocilia. However, it remains unclear whether TMC1 and TMC2 are indeed ion channels and whether they can sense mechanical force directly. Here we express TMC1 from the green sea turtle (CmTMC1) and TMC2 from the budgerigar (MuTMC2) in...

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Identifiers

PMID: 31761710
DOI: 10.1016/j.neuron.2019.10.017

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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TMC1 and TMC2 Proteins Are Pore-Forming Subunits of Mechanosensitive Ion Channels.PMID 31761710Read ↗

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Function and Dysfunction of TMC Channels in Inner Ear Hair Cells.Semantic proximity Read ↗

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The effects of Tmc1 Beethoven mutation on mechanotransducer channel function in cochlear hair cells.Semantic proximity Read ↗

CIB2 interacts with TMC1 and TMC2 and is essential for mechanotransduction in auditory hair cells.Semantic proximity Read ↗

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