Article
Tmc proteins are essential for zebrafish hearing where Tmc1 is not obligatory.
Human molecular genetics - 29 Jul 2020
Chen Zongwei, Zhu Shaoyuan, Kindig Kayla, Wang Shengxuan, Chou Shih-Wei, Davis Robin Woods, Dercoli Michael R, Weaver Hannah, Stepanyan Ruben, McDermott Brian M
Abstract excerpt
Perception of sound is initiated by mechanically gated ion channels at the tips of stereocilia. Mature mammalian auditory hair cells require transmembrane channel-like 1 (TMC1) for mechanotransduction, and mutations of the cognate genetic sequences result in dominant or recessive heritable deafness forms in humans and mice. In contrast, zebrafish lateral line hair cells, which detect water motion, require Tmc2a...
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