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Article

CIB2 interacts with TMC1 and TMC2 and is essential for mechanotransduction in auditory hair cells.

Nature communications - 29 Jun 2017

Giese Arnaud P J, Tang Yi-Quan, Sinha Ghanshyam P, Bowl Michael R, Goldring Adam C, Parker Andrew, Freeman Mary J, Brown Steve D M, Riazuddin Saima, Fettiplace Robert, Schafer William R, Frolenkov Gregory I, Ahmed Zubair M

Abstract excerpt

Inner ear hair cells detect sound through deflection of stereocilia, the microvilli-like projections that are arranged in rows of graded heights. Calcium and integrin-binding protein 2 is essential for hearing and localizes to stereocilia, but its exact function is unknown. Here, we have characterized two mutant mouse lines, one lacking calcium and integrin-binding protein 2 and one carrying a human...

Topics

Animals
Calcium-Binding Proteins
Deafness
Gene Expression Regulation
HEK293 Cells
Hair Cells, Auditory
Humans
Mechanotransduction, Cellular
Membrane Proteins
Mice

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Mutation

Patch-Clamp Techniques

Source

Open in PubMed Open full text

Identifiers

PMID: 28663585
DOI: 10.1038/s41467-017-00061-1
PMCID: PMC5491523

Genes

CIB2
TMC1
TMC2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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CIB2 interacts with TMC1 and TMC2 and is essential for mechanotransduction in auditory hair cells.PMID 28663585Read ↗

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CIB2, defective in isolated deafness, is key for auditory hair cell mechanotransduction and survival.Semantic proximity Read ↗

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The Diverse Functions of the Calcium- and Integrin-Binding Protein FamilySemantic proximity Read ↗

CIB2 function is distinct from that of whirlin in the organization of sterocilia architecture.Semantic proximity Read ↗

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