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Article

TMC1 and TMC2 are components of the mechanotransduction channel in hair cells of the mammalian inner ear.

Neuron - 7 Aug 2013

Pan Bifeng, Géléoc Gwenaelle S, Asai Yukako, Horwitz Geoffrey C, Kurima Kiyoto, Ishikawa Kotaro, Kawashima Yoshiyuki, Griffith Andrew J, Holt Jeffrey R

Abstract excerpt

Sensory transduction in auditory and vestibular hair cells requires expression of transmembrane channel-like (Tmc) 1 and 2 genes, but the function of these genes is unknown. To investigate the hypothesis that TMC1 and TMC2 proteins are components of the mechanosensitive ion channels that convert mechanical information into electrical signals, we recorded whole-cell and single-channel currents from mouse hair...

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Source

Open in PubMed Open full text

Identifiers

PMID: 23871232
DOI: 10.1016/j.neuron.2013.06.019
PMCID: PMC3827726

Genes

TMC1
TMC2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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TMC1 and TMC2 are components of the mechanotransduction channel in hair cells of the mammalian inner ear.PMID 23871232Read ↗

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