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Deafness mutation D572N of TMC1 destabilizes TMC1 expression by disrupting LHFPL5 binding

9 Nov 2020

Abstract excerpt

Transmembrane channel-like protein 1 (TMC1) and lipoma HMGIC fusion partner-like 5 (LHFPL5) are recognized as two critical components of the mechanotransduction complex in inner-ear hair cells. However, the physical and functional interactions of TMC1 and LHFPL5 remain largely unexplored. We examined the interaction between TMC1 and LHFPL5 by using multiple approaches, including our recently developed...

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PMID: 33168709
DOI: 10.1073/pnas.2011147117

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