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Article

Mechanosensory hair cells express two molecularly distinct mechanotransduction channels.

Nature neuroscience - 1 Jan 2017

Wu Zizhen, Grillet Nicolas, Zhao Bo, Cunningham Christopher, Harkins-Perry Sarah, Coste Bertrand, Ranade Sanjeev, Zebarjadi Navid, Beurg Maryline, Fettiplace Robert, Patapoutian Ardem, Mueller Ulrich

Abstract excerpt

Auditory hair cells contain mechanotransduction channels that rapidly open in response to sound-induced vibrations. We report here that auditory hair cells contain two molecularly distinct mechanotransduction channels. One ion channel is activated by sound and is responsible for sensory transduction. This sensory transduction channel is expressed in hair cell stereocilia, and previous studies show that its...

Topics

Animals
Calcium
Hair
Hair Cells, Auditory
Mechanotransduction, Cellular
Membrane Proteins
Mice, Knockout
Mutation
Stereocilia

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Open in PubMed Open full text

Identifiers

PMID: 27893727
DOI: 10.1038/nn.4449
PMCID: PMC5191906

Genes

TMC1
TMC2
TMIE

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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