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Article

Function and Dysfunction of TMC Channels in Inner Ear Hair Cells.

Cold Spring Harbor perspectives in medicine - 1 Oct 2019

Corey David P, Akyuz Nurunisa, Holt Jeffrey R

Abstract excerpt

The TMC1 channel was identified as a protein essential for hearing in mouse and human, and recognized as one of a family of eight such proteins in mammals. The TMC family is part of a superfamily of seven branches, which includes the TMEM16s. Vertebrate hair cells express both TMC1 and TMC2. They are located at the tips of stereocilia and are required for hair cell mechanotransduction. TMC1 assembles as a dimer...

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Topics

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Share to PCDH15 gene
Share to Hair Cells, Auditory, Inner
Share to Mechanotransduction, Cellular

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Open in PubMed Open full text

Identifiers

PMID: 30291150
DOI: 10.1101/cshperspect.a033506
PMCID: PMC6450785

Genes

TMC1
TMC2
CIB2
LHFPL5
PCDH15
TMIE

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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