Article

Putative pore-forming subunits of the mechano-electrical transduction channel, Tmc1/2b, require Tmie to localize to the site of mechanotransduction in zebrafish sensory hair cells

2018-08-16

Abstract excerpt

Mutations in transmembrane inner ear ( TMIE) cause deafness in humans; previous studies suggest involvement in the mechano-electrical transduction (MET) complex in sensory hair cells, but TMIE’s precise role is unclear. In tmie zebrafish mutants, we observed that GFP-tagged Tmc1 and Tmc2b, which are putative subunits of the MET channel, fail to target to the hair bundle. In contrast, overexpression of Tmie stron...

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Literature Corpus work: 9e9fc700-19f7-54d3-be5a-30e15d035219
DOI: 10.1101/393330

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