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Article

The effects of Tmc1 Beethoven mutation on mechanotransducer channel function in cochlear hair cells.

The Journal of general physiology - 1 Sept 2015

Beurg Maryline, Goldring Adam C, Fettiplace Robert

Abstract excerpt

Sound stimuli are converted into electrical signals via gating of mechano-electrical transducer (MT) channels in the hair cell stereociliary bundle. The molecular composition of the MT channel is still not fully established, although transmembrane channel-like protein isoform 1 (TMC1) may be one component. We found that in outer hair cells of Beethoven mice containing a M412K point mutation in TMC1, MT channels...

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Share to Calcium
Share to Calcium Signaling
Share to Hair Cells, Auditory

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Hearing Loss

Share to Mechanotransduction, Cellular

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Source

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Identifiers

PMID: 26324676
DOI: 10.1085/jgp.201511458
PMCID: PMC4555472

Genes

TMC1

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

Related research

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The effects of Tmc1 Beethoven mutation on mechanotransducer channel function in cochlear hair cells.PMID 26324676Read ↗

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TMC1 and TMC2 Proteins Are Pore-Forming Subunits of Mechanosensitive Ion Channels.Semantic proximity Read ↗

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