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Article

Conductance and block of hair-cell mechanotransducer channels in transmembrane channel-like protein mutants.

The Journal of general physiology - 1 Jul 2014

Beurg Maryline, Kim Kyunghee X, Fettiplace Robert

Abstract excerpt

Transmembrane channel-like (TMC) proteins TMC1 and TMC2 are crucial to the function of the mechanotransducer (MT) channel of inner ear hair cells, but their precise function has been controversial. To provide more insight, we characterized single MT channels in cochlear hair cells from wild-type mice and mice with mutations in Tmc1, Tmc2, or both. Channels were recorded in whole-cell mode after tip link...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Hair Cells, Auditory

Share to Mechanotransduction, Cellular

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Source

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Identifiers

PMID: 24981230
DOI: 10.1085/jgp.201411173
PMCID: PMC4076520

Genes

TMC1
TMC2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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