Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Topics Community

Article

Mutations of TMC1 cause deafness by disrupting mechanoelectrical transduction.

Auris, nasus, larynx - 1 Oct 2014

Nakanishi Hiroshi, Kurima Kiyoto, Kawashima Yoshiyuki, Griffith Andrew J

Abstract excerpt

OBJECTIVE: Mutations of transmembrane channel-like 1 gene (TMC1) can cause dominant (DFNA36) or recessive (DFNB7/B11) deafness. In this article, we describe the characteristics of DFNA36 and DFNB7/B11 deafness, the features of the Tmc1 mutant mouse strains, and recent advances in our understanding of TMC1 function. METHODS: Publications related to TMC1, DFNA36, or DFNB7/B11 were identified through PubMed....

Topics

Animals
Deafness
Disease Models, Animal
Hair Cells, Auditory
Hearing Loss, Sensorineural
Humans
Membrane Proteins
Mice
Mutation

Source

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Identifiers

PMID: 24933710
DOI: 10.1016/j.anl.2014.04.001
PMCID: PMC4176506

Genes

TMC1
MET
TMC2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

0

discussions

0

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Mutations of TMC1 cause deafness by disrupting mechanoelectrical transduction.PMID 24933710Read ↗

[Advances in hereditary hearing loss caused by TMC1 mutations].Semantic proximity Read ↗

Dominant and recessive deafness caused by mutations of a novel gene, TMC1, required for cochlear hair-cell function.Semantic proximity Read ↗

A novel DFNA36 mutation in TMC1 orthologous to the Beethoven (Bth) mouse associated with autosomal dominant hearing loss in a Chinese family.Semantic proximity Read ↗

Beethoven, a mouse model for dominant, progressive hearing loss DFNA36.Semantic proximity Read ↗

Is TMC1 the Hair Cell Mechanotransducer Channel?Semantic proximity Read ↗

Tmc2 expression partially restores auditory function in a mouse model of DFNB7/B11 deafness caused by loss of Tmc1 function.Semantic proximity Read ↗

Function and Dysfunction of TMC Channels in Inner Ear Hair Cells.Semantic proximity Read ↗

TMC1 and TMC2 are components of the mechanotransduction channel in hair cells of the mammalian inner ear.Semantic proximity Read ↗

Identification of TMC1 as a relatively common cause for nonsyndromic hearing loss in the Saudi population.Semantic proximity Read ↗

Mouse tales from Kresge: the deafness mouse.Semantic proximity Read ↗

Tmc proteins are essential for zebrafish hearing where Tmc1 is not obligatory.Semantic proximity Read ↗

Genetics of Hearing and DeafnessSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.