Article
Discovery of novel amino acid production traits by evolution of synthetic co-cultures.
Microbial cell factories - 15 Apr 2023
Zuchowski Rico, Schito Simone, Neuheuser Friederike, Menke Philipp, Berger Daniel, Hollmann Niels, Gujar Srushti, Sundermeyer Lea, Mack Christina, Wirtz Astrid, Weiergräber Oliver H, Polen Tino, Bott Michael, Noack Stephan, Baumgart Meike
Abstract excerpt
BACKGROUND: Amino acid production features of Corynebacterium glutamicum were extensively studied in the last two decades. Many metabolic pathways, regulatory and transport principles are known, but purely rational approaches often provide only limited progress in production optimization. We recently generated stable synthetic co-cultures, termed Communities of Niche-optimized Strains (CoNoS), that rely on...
Topics
- Amino Acids
- Leucine
- Coculture Techniques
- Mutation
- Arginine
- Corynebacterium glutamicum
- Metabolic Engineering