Mutations in the ilvN gene mitigate growth inhibitory effect of cysteine in Corynebacterium glutamicum.

doi:10.1007/s00253-025-13444-y

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Article

Mutations in the ilvN gene mitigate growth inhibitory effect of cysteine in Corynebacterium glutamicum.

Applied microbiology and biotechnology - 10 Mar 2025

Matsuhisa Kazuho, Ogawa Katsuhiro, Komata Kento, Hirasawa Takashi

Abstract excerpt

Cysteine, a common amino acid used in food, cosmetic, and pharmaceutical industries, has a growth inhibitory effect. This growth inhibition by cysteine poses a problem, as the production of cysteine using microbial cells results in decreased cell growth and cysteine productivity. The underlying m...

Topics

Corynebacterium glutamicum
Cysteine
Acetolactate Synthase
Mutation
Valine
Bacterial Proteins

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