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Article

The impact of disregarding family structure on genome-wide association analysis of complex diseases in cohorts with simple pedigrees.

Journal of applied genetics - 1 Feb 2020

Nazarian Alireza, Arbeev Konstantin G, Kulminski Alexander M

Abstract excerpt

The generalized linear mixed models (GLMMs) methodology is the standard framework for genome-wide association studies (GWAS) of complex diseases in family-based cohorts. Fitting GLMMs in very large cohorts, however, can be computationally demanding. Also, the modified versions of GLMM using faster algorithms may underperform, for instance when a single nucleotide polymorphism (SNP) is correlated with...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 31755004
DOI: 10.1007/s13353-019-00526-7
PMCID: PMC6980752

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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