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Article

Modeling the Dependence Structure in Genome Wide Association Studies of Binary Phenotypes in Family Data.

Behavior genetics - 1 Nov 2020

Seal Souvik, Boatman Jeffrey A, McGue Matt, Basu Saonli

Abstract excerpt

Genome-wide association studies (GWASs) are a popular tool for detecting association between genetic variants or single nucleotide polymorphisms (SNPs) and complex traits. Family data introduce complexity due to the non-independence of the family members. Methods for non-independent data are well established, but when the GWAS contains distinct family types, explicit modeling of between-family-type differences in...

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PMID: 32804302
DOI: 10.1007/s10519-020-10010-2
PMCID: PMC7581561

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