The effect of family structure on the still-missing heritability and genomic prediction accuracy of type 2 diabetes.

doi:10.1186/s40246-024-00669-7

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Article

The effect of family structure on the still-missing heritability and genomic prediction accuracy of type 2 diabetes.

Human genomics - 11 Sept 2024

Amiri Roudbar Mahmoud, Vahedi Seyed Milad, Jin Jin, Jahangiri Mina, Lanjanian Hossein, Habibi Danial, Masjoudi Sajedeh, Riahi Parisa, Fateh Sahand Tehrani, Neshati Farideh, Zahedi Asiyeh Sadat, Moazzam-Jazi Maryam, Najd-Hassan-Bonab Leila, Mousavi Seyedeh Fatemeh, Asgarian Sara, Zarkesh Maryam, Moghaddas Mohammad Reza, Tenesa Albert, Kazemnejad Anoshirvan, Vahidnezhad Hassan, Hakonarson Hakon, Azizi Fereidoun, Hedayati Mehdi, Daneshpour Maryam Sadat, Akbarzadeh Mahdi

Abstract excerpt

This study aims to assess the effect of familial structures on the still-missing heritability estimate and prediction accuracy of Type 2 Diabetes (T2D) using pedigree estimated risk values (ERV) and genomic ERV. We used 11,818 individuals (T2D cases: 2,210) with genotype (649,932 SNPs) and pedigree information from the ongoing periodic cohort study of the Iranian population project. We considered three different...

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PMID: 39256828
DOI: 10.1186/s40246-024-00669-7
PMCID: PMC11389528

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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