Article
Estimation of genetic effects in multiple cases family studies using penalized maximum likelihood methodology.
Biostatistics (Oxford, England) - 1 Apr 2013
Tsonaka Roula, De Visser Marieke C H, Houwing-Duistermaat Jeanine
Abstract excerpt
Family studies are often used in genetic research to explore associations between genetic markers and various phenotypes. A commonly used design oversamples families enriched with the disease under study for efficient data collection and estimation. For instance, in a multiple cases family study, families are selected based on the number of affected relatives. In such cases, valid inference for the model...
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