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Article

Detecting mtDNA Effects with an Extended Pedigree Model: An Analysis of Statistical Power and Estimation Bias.

Behavior genetics - 1 Jul 2025

Lyu Xuanyu, Hunter Michael D, Burt S Alexandra, Good Rachel, Carroll Sarah L, Mason Garrison S

Abstract excerpt

Mitochondrial DNA (mtDNA) plays a crucial role in numerous cellular processes, yet its impact on human complex behavior remains underexplored. The current paper proposes a novel covariance structure model with seven parameters to specifically isolate and quantify mtDNA effects on human complex traits. This approach uses extended pedigrees to obtain estimates of mtDNA variance while controlling for other genetic...

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Identifiers

PMID: 40668274
DOI: 10.1007/s10519-025-10225-1
PMCID: PMC12325453

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