Article
Generation and comparison of CRISPR-Cas9 and Cre-mediated genetically engineered mouse models of sarcoma.
Nature communications - 10 Jul 2017
Huang Jianguo, Chen Mark, Whitley Melodi Javid, Kuo Hsuan-Cheng, Xu Eric S, Walens Andrea, Mowery Yvonne M, Van Mater David, Eward William C, Cardona Diana M, Luo Lixia, Ma Yan, Lopez Omar M, Nelson Christopher E, Robinson-Hamm Jacqueline N, Reddy Anupama, Dave Sandeep S, Gersbach Charles A, Dodd Rebecca D, Kirsch David G
Abstract excerpt
Genetically engineered mouse models that employ site-specific recombinase technology are important tools for cancer research but can be costly and time-consuming. The CRISPR-Cas9 system has been adapted to generate autochthonous tumours in mice, but how these tumours compare to tumours generated by conventional recombinase technology remains to be fully explored. Here we use CRISPR-Cas9 to generate multiple...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.