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Article

Essential role for the CRAC activation domain in store-dependent oligomerization of STIM1.

Molecular biology of the cell - 1 Jun 2010

Covington Elizabeth D, Wu Minnie M, Lewis Richard S

Abstract excerpt

Oligomerization of the ER Ca(2+) sensor STIM1 is an essential step in store-operated Ca(2+) entry. The lumenal EF-hand and SAM domains of STIM1 are believed to initiate oligomerization after Ca(2+) store depletion, but the contributions of STIM1 cytosolic domains (coiled-coil 1, CC1; coiled-coil 2, CC2; CRAC activation domain, CAD) to this process are not well understood. By applying coimmunoprecipitation and...

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Source

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Identifiers

PMID: 20375143
DOI: 10.1091/mbc.e10-02-0145
PMCID: PMC2877647

Genes

STIM1
CAD

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

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Essential role for the CRAC activation domain in store-dependent oligomerization of STIM1.PMID 20375143Read ↗

Mapping the interacting domains of STIM1 and Orai1 in Ca2+ release-activated Ca2+ channel activation.Semantic proximity Read ↗

Molecular anatomy of the early events in STIM1 activation - oligomerization or conformational change?Semantic proximity Read ↗

STIM1/Orai1 coiled-coil interplay in the regulation of store-operated calcium entry.Semantic proximity Read ↗

Intramolecular shielding maintains the ER Ca²⁺ sensor STIM1 in an inactive conformation.Semantic proximity Read ↗

Review: Structure and Activation Mechanisms of CRAC Channels.Semantic proximity Read ↗

Sequential activation of STIM1 links Ca2+ with luminal domain unfolding.Semantic proximity Read ↗

STIM1 is a Ca2+ sensor that activates CRAC channels and migrates from the Ca2+ store to the plasma membrane.Semantic proximity Read ↗

Sequential Steps of CRAC Channel Activation.Semantic proximity Read ↗

Physiological CRAC channel activation and pore properties require STIM1 binding to all six Orai1 subunits.Semantic proximity Read ↗

STIM1 carboxyl-terminus activates native SOC, I(crac) and TRPC1 channels.Semantic proximity Read ↗

CRACM1, CRACM2, and CRACM3 are store-operated Ca2+ channels with distinct functional properties.Semantic proximity Read ↗

Live-cell imaging reveals sequential oligomerization and local plasma membrane targeting of stromal interaction molecule 1 after Ca2+ store depletion.Semantic proximity Read ↗

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