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Article

Luminal STIM1 Mutants that Cause Tubular Aggregate Myopathy Promote Autophagic Processes.

International journal of molecular sciences - 21 Jun 2020

Sallinger Matthias, Tiffner Adéla, Schmidt Tony, Bonhenry Daniel, Waldherr Linda, Frischauf Irene, Lunz Victoria, Derler Isabella, Schober Romana, Schindl Rainer

Abstract excerpt

Stromal interaction molecule 1 (STIM1) is a ubiquitously expressed Ca2+ sensor protein that induces permeation of Orai Ca2+ channels upon endoplasmic reticulum Ca2+-store depletion. A drop in luminal Ca2+ causes partial unfolding of the N-terminal STIM1 domains and thus initial STIM1 activation. We compared the STIM1 structure upon Ca2+ depletion from our molecular dynamics (MD) simulations with a recent 2D NMR...

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Source

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Identifiers

PMID: 32575830
DOI: 10.3390/ijms21124410
PMCID: PMC7352373

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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Luminal STIM1 Mutants that Cause Tubular Aggregate Myopathy Promote Autophagic Processes.PMID 32575830Read ↗

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