Article
The PUF RNA-binding protein, FBF-2, maintains stem cells without binding to RNA.
RNA (New York, N.Y.) - 16 Apr 2025
Carrick Brian H, Crittenden Sarah L, Linsley MaryGrace, Dos Santos Stephany J Costa, Wickens Marvin, Kimble Judith
Abstract excerpt
Like all canonical PUF proteins, Caenorhabditis elegans FBF-2 binds to specific RNAs via tripartite recognition motifs. Here, we report that an FBF-2 mutant protein that cannot bind to RNA is nonetheless biologically active and maintains stem cells. This unexpected result challenges the conventional wisdom that RBPs must bind to RNAs to achieve biological activity. Also unexpectedly, FBF-2 interactions with...
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