Article
A conserved RNA-binding protein controls germline stem cells in Caenorhabditis elegans.
Nature - 6 Jun 2002
Crittenden Sarah L, Bernstein David S, Bachorik Jennifer L, Thompson Beth E, Gallegos Maria, Petcherski Andrei G, Moulder Gary, Barstead Robert, Wickens Marvin, Kimble Judith
Abstract excerpt
Germline stem cells are defined by their unique ability to generate more of themselves as well as differentiated gametes. The molecular mechanisms controlling the decision between self-renewal and differentiation are central unsolved problems in developmental biology with potentially broad medical implications. In Caenorhabditis elegans, germline stem cells are controlled by the somatic distal tip cell. FBF-1 and...
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