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Article

Cdr1p highlights the role of the non-hydrolytic ATP-binding site in driving drug translocation in asymmetric ABC pumps.

Biochimica et biophysica acta. Biomembranes - 1 Feb 2020

Banerjee Atanu, Moreno Alexis, Khan Mohammad Firoz, Nair Remya, Sharma Suman, Sen Sobhan, Mondal Alok Kumar, Pata Jorgaq, Orelle Cédric, Falson Pierre, Prasad Rajendra

Abstract excerpt

ATP-binding cassette (ABC) transporters couple ATP binding and hydrolysis to the translocation of allocrites across membranes. Two shared nucleotide-binding sites (NBS) participate in this cycle. In asymmetric ABC pumps, only one of them hydrolyzes ATP, and the functional role of the other remains unclear. Using a drug-based selection strategy on the transport-deficient mutant L529A in the transmembrane domain of...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 31734312
DOI: 10.1016/j.bbamem.2019.183131

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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