Article
A conserved interdomain communication pathway of pseudosymmetrically distributed residues affects substrate specificity of the fungal multidrug transporter Cdr1p.
Biochimica et biophysica acta - 1 Feb 2013
Kolaczkowski Marcin, Sroda-Pomianek Kamila, Kolaczkowska Anna, Michalak Krystyna
Abstract excerpt
Understanding the communication pathways between remote sites in proteins is of key importance for understanding their function and mechanism of action. These remain largely unexplored among the pleiotropic drug resistance (PDR) representatives of the ubiquitous superfamily of ATP-binding cassette (ABC) transporters. To identify functionally coupled residues important for the polyspecific transport by the fungal...
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