Article
Newly identified motifs in Candida albicans Cdr1 protein nucleotide binding domains are pleiotropic drug resistance subfamily-specific and functionally asymmetric.
Scientific reports - 2 Jun 2016
Rawal Manpreet Kaur, Banerjee Atanu, Shah Abdul Haseeb, Khan Mohammad Firoz, Sen Sobhan, Saxena Ajay Kumar, Monk Brian C, Cannon Richard D, Bhatnagar Rakesh, Mondal Alok Kumar, Prasad Rajendra
Abstract excerpt
An analysis of Candida albicans ABC transporters identified conserved related α-helical sequence motifs immediately C-terminal of each Walker A sequence. Despite the occurrence of these motifs in ABC subfamilies of other yeasts and higher eukaryotes, their roles in protein function remained unexplored. In this study we have examined the functional significance of these motifs in the C. albicans PDR transporter...
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