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Article

TTC5 mediates autoregulation of tubulin via mRNA degradation.

Science (New York, N.Y.) - 3 Jan 2020

Lin Zhewang, Gasic Ivana, Chandrasekaran Viswanathan, Peters Niklas, Shao Sichen, Mitchison Timothy J, Hegde Ramanujan S

Abstract excerpt

Tubulins play crucial roles in cell division, intracellular traffic, and cell shape. Tubulin concentration is autoregulated by feedback control of messenger RNA (mRNA) degradation via an unknown mechanism. We identified tetratricopeptide protein 5 (TTC5) as a tubulin-specific ribosome-associating factor that triggers cotranslational degradation of tubulin mRNAs in response to excess soluble tubulin. Structural...

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Identifiers

PMID: 31727855
DOI: 10.1126/science.aaz4352
PMCID: PMC6942541

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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