Article

Tubulin autoregulation tunes microtubule dynamics to support multicellular architecture and viability

2025-07-30

Abstract excerpt

Alpha- and beta-tubulin heterodimers dynamically assemble into microtubules, key cytoskeletal elements involved in intracellular trafficking, cell adhesion and division. The availability of free tubulins regulates the synthesis of new subunits. In response to excessive soluble αβ-tubulins, tetratricopeptide protein 5 (TTC5) selectively recognizes nascent tubulins at the ribosome, recruiting downstream effectors th...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: dbad71fe-7cfb-5d0a-bf1d-03e9be65cb58
DOI: 10.1101/2025.07.28.667019

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Tubulin autoregulation tunes microtubule dynamics to support multicellular architecture and viabilityDOI 10.1101/2025.07.28.667019Read

Tubulin autoregulation mediator TTC5 regulates neuronal morphology and migrationSemantic proximity Read

TTC5 mediates autoregulation of tubulin via mRNA degradation.Semantic proximity Read

The emerging role of the tubulin code: From the tubulin molecule to neuronal function and disease.Semantic proximity Read

The Tubulin Code and Tubulin-Modifying Enzymes in Autophagy and CancerSemantic proximity Read

An ensemble of specifically targeted proteins stabilizes cortical microtubules in the human parasiteToxoplasma gondiiSemantic proximity Read

Multiple tubulins: evolutionary aspects and biological implications.Semantic proximity Read

Heterogeneous Tau-Tubulin Complexes Accelerate Microtubule Polymerization.Semantic proximity Read

Mutation of the α-tubulin Tuba1a leads to straighter microtubules and perturbs neuronal migration.Semantic proximity Read

Tubulin Posttranslational Modifications and Emerging Links to Human Disease.Semantic proximity Read

A molecular and spatial resource defining tubulin isotype organization during corneal developmentSemantic proximity Read

Distinct alpha- and beta-tubulin isotypes are required for the positioning, differentiation and survival of neurons: new support for the 'multi-tubulin' hypothesis.Semantic proximity Read

Mechanism of ribosome-associated mRNA degradation during tubulin autoregulationSemantic proximity Read