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Recent advances in signal integration mechanisms in the unfolded protein response

1 Nov 2019

Abstract excerpt

Since its discovery more than 25 years ago, great progress has been made in our understanding of the unfolded protein response (UPR), a homeostatic mechanism that adjusts endoplasmic reticulum (ER) function to satisfy the physiological demands of the cell. However, if ER homeostasis is unattainable, the UPR switches to drive cell death to remove defective cells in an effort to protect the health of the organism....

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PMID: 31723416
DOI: 10.12688/f1000research.19848.1

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