The UPR and cell fate at a glance

Abstract excerpt

In eukaryotic cells, secreted and resident proteins of the endomembrane system fold into their native structures within the endoplasmic reticulum (ER). The ER is a network of membranous tubules and sheets whose lumenal environment is crowded with molecular chaperones and protein-modification enzymes that are specialized to fold proteins. In addition, the ER contains stringent quality-control systems that...

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