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Article

Endoplasmic reticulum stress signaling: the microRNA connection

21 Mar 2013

Abstract excerpt

The endoplasmic reticulum (ER)-induced unfolded protein response (ERUPR) is an adaptive mechanism that is activated upon accumulation of misfolded proteins in the ER and aims at restoring ER homeostasis. The ERUPR is transduced by three major ER-resident stress sensors, namely PKR-like endoplasmic reticulum kinase (PERK), activating transcription factor 6 (ATF6), and inositol requiring enzyme 1 (IRE1). Activation...

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PMID: 23515532
DOI: 10.1152/ajpcell.00061.2013

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