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Article

Identification of a psychiatric risk gene NISCH at 3p21.1 GWAS locus mediating dendritic spine morphogenesis and cognitive function.

BMC medicine - 13 Jul 2023

Yang Zhi-Hui, Cai Xin, Ding Zhong-Li, Li Wei, Zhang Chu-Yi, Huo Jin-Hua, Zhang Yue, Wang Lu, Zhang Lin-Ming, Li Shi-Wu, Li Ming, Zhang Chen, Chang Hong, Xiao Xiao

Abstract excerpt

BACKGROUND: Schizophrenia and bipolar disorder (BD) are believed to share clinical symptoms, genetic risk, etiological factors, and pathogenic mechanisms. We previously reported that single nucleotide polymorphisms spanning chromosome 3p21.1 showed significant associations with both schizophrenia and BD, and a risk SNP rs2251219 was in linkage disequilibrium with a human specific Alu polymorphism rs71052682,...

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PMID: 37443018
DOI: 10.1186/s12916-023-02931-6
PMCID: PMC10347724

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